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ea0037ep1071 | Thyroid (non-cancer) | ECE2015

Could thyroid replacement therapy not be enough to reduce oxidative stress in hypothyroid patients with Down' syndrome? A cohort study

Villani Emanuele Rocco , Onder Graziano , Carfi Angelo , Pagano Francesco , Raimondo Sebastiano , Di Segni Chantal , Silvestrini Andrea , Meucci Elisabetta , Mancini Antonio

Hypothyroidism and autoimmune thyroiditis are common in patients with Down syndrome (DS), leading to common prescription of thyroid replacement therapy. On the other hand, thyroid function is involved in oxidative stress (OS) mechanisms. DS is a well-known high OS condition because several genes involved in OS mechanisms map on chromosome 21 and coenzyme Q10, lipophilic antioxidant, could be more correlated with hypothyroidism than TSH in DS people. To investigate relati...

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Could thyroid replacement therapy not be enough to reduce oxidative stress in hypothyroid patients with Down' syndrome? A cohort study

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